Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

Autoantibody Profiling in Multiple Sclerosis

Microbial Host Engineering: beyond the Metabolic Pathway

As the focus of microbial metabolic engineering shifts to include bulk commodities, two aspects of this research have become increasingly important. One is the requirement for high production titers in order to make the process economically viable. The second is to engineer microbes that are tolerant to these target products, many of which are toxic to cell growth. This review focuses on recent...

Impairment, disability and fatigue in multiple sclerosis

Background: Identifying the predictors of pain is important for both health professionals and researchers, because pain has repeatedly been found to be a strong predictor of activity limitations and participation restrictions. The objective of this study was to determine the predictors of pain presence and severity in a large, well-designed sample of community dwelling individuals with multip...

Colonization-Induced Host-Gut Microbial Metabolic Interaction

UNLABELLED The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical environmental microbial background using high-resolution (1)H nuclear magnet...

Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk.

BACKGROUND AND AIMS Bariatric surgery is increasingly performed worldwide to treat morbid obesity and is also known as metabolic surgery to reflect its beneficial metabolic effects especially with respect to improvement in type 2 diabetes. Understanding surgical weight loss mechanisms and metabolic modulation is required to enhance patient benefits and operative outcomes. METHODS The authors ...